Research Overview

Arabidopsis controlled growth facilities

Our Genetics and Biotechnology Lab is using a range of functional genomics (wet lab molecular genetics combined with bioinformatics) approaches to investigate both fundamental and applied aspects of genetics and epigenetics. Our lab uses model genetic systems such as the plant Arabidopsis thaliana and mammalian cell systems to investigate biological questions.

We investigate the evolution and regulation of genes which display epigenetic (non-Mendelian) modes of inheritance. These include autosomal genes subject to genomic imprinting which are differentially expressed depending on their parent-of-origin. We are also investigating the genetics and epigenetics of gene and genome dosage effects which can be observed in polyploid genomes of plants. Using the ICHEC supercomputer based at NUI Galway, we combine whole-genome bioinformatics approaches with functional genomics to understand the origins, molecular evolution and functions of novel, duplicated and conserved genes, with a specific focus on genes which are of importance to stress tolerance, plant reproduction and seed development. Our lab also conducts research on functional genomics and epigenetics of gene regulation via non-coding microRNAs, with a specific focus on understanding miRNA-signalling pathways and regulatory networks in mammalian cells.

Molecular biology in Spillane lab

Our research objectives and projects span from fundamental research to biotechnological applications using a wide range of biological organisms. While most of our genetics and epigenetics research is based on the model plant Arabidopsis thaliana, our non-coding RNA research activities are based on mammalian cell systems. In some instances we also tailor research questions to specific organisms. Hence we are also conducting molecular genetics research using other organisms including cattle, Phaseolus beans, East African highland bananas, maize and microalgal cells.

We also conduct research on science policy relating to genetics and biotechnology issues, particularly in relation to importance of plant genetics and agricultural biotechnologies for developing countries.