Research Interests
- DNA damage response pathways in human mesenchymal stem cells and normal primary melanocytes
- Mechanistic investigation of the cellular response to DNA damage-induced replication arrest
Research Interests
- Centromere assembly and propagation in meiosis and early development
Research Interests
- Design principles of the nucleosome
- Mechanism of ATP-dependent remodelling
- Role of chromatin structure in DNA repair and in centromere function
Research Interests
- DNA mutagenesis and repair
- Trinucleotide repeat instability
Research Interests
- Biological responses to DNA damage in eukaryotic model systems
- Epigenetic regulation of the DNA damage response
- Identification and characterisation of new DDR activities
Research Interests
- The organisation of ribosomal gene arrays
- Formation of the nucleolus in human cells
Research Interests
- How DNA damage impacts on centrosome duplication, cohesion and ciliogenesis
- Roles of the centrosomal/ pericentriolar material components, Pericentrin and Mcph1, in cell cycle control
- Activities of centrosome proteins (centrin, Cep164, Cep290) in DNA repair
- Regulation of centrosome and centriole cohesion
Research Interests
- Mechanisms and regulation of human DNA replication
- DNA damage-induced re-localization of DNA repair proteins in mitosis
- Protein-protein interactions in living cells
- DNA replication of human polyoma viruses
Research Interests
- Epigenetic regulation of gene expression
- Histone modifications in normal development and disease
Research Interests
- Mechanisms of genome replication: function and regulation of Cdc7 kinase
- Cancer therapeutics
Research Interests
- Centromere replication: epigenetic chromosome inheritance
- Mitotic checkpoints, apoptosis and cancer chemotherapeutics
- Quantitative microscopy and phenotypic analysis of cells
